I think a lot more concern on the series future lies in the fact that most of the people responsible for the series more popular entries, no longer have anything to do with the franchise.
The newer teams have many more tools at their disposal to make games, and seem to be limited by capcoms 'rinse, lather, repeat' methodology.
I'm actually more concerned with RE6 going the 'bigger is better' route in terms of settings and what not.
I keep expecting to see a BOW the size of mt. Everest at this point in the series.